Selected Publications

Articles In Academic Journals

Year Title
2018 Nano-pulse stimulation ablates orthotopic rat hepatocellular carcinoma and induces innate and adaptive memory immune mechanisms that prevent recurrenceCancers. 1-9.
2015 Considering effects of nanosecond pulsed electric fields on proteins.Bioelectrochemistry (Amsterdam, Netherlands). 52-9.
2015 Mechanisms of nanosecond pulsed electric field (nsPEF)-induced cell death in cells and tumorsJournal of Nanomedicine Research.
2014 A protective effect after clearance of orthotopic rat hepatocellular carcinoma by nanosecond pulsed electric fields.European Journal of Cancer. 2705-2713.
2013 Applications for pulse power using nanosecond pulsed electric fields (nsPEFs) in cell biology and cancer treatmentJournal of Nanomedicine and Biotherapeutic Discovery.
2013 Bioelectrics in basic science and medicine: impact of electric fields on cellular structures and functionsJournal of Nanomedicine and Nanotechnology.
2013 Induction of Cell Death Mechanisms and Apoptosis by Nanosecond Pulsed Electric Fields (nsPEFs).Cells. 136-62.
2012 Long term survival of mice with hepatocellular carcinoma after pulse power ablation with nanosecond pulsed electric fields.Technology in Cancer Research & Treatment. 83-93.
2012 Nanosecond pulsed electric fields (nsPEFs) activate intrinsic caspase-dependent and caspase-independent cell death in Jurkat cells.Biochemical and biophysical research communications. 808-12.
2012 Synergistic effects of nanosecond pulsed electric fields combined with low concentration of gemcitabine on human oral squamous cell carcinoma in vitro.PLOS ONE. e43213.
2012 Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability.PLOS ONE. e51349.
2011 An apoptosis targeted stimulus with nanosecond pulsed electric fields (nsPEFs) in E4 squamous cell carcinoma.Apoptosis : an international journal on programmed cell death. 382-93.
2011 Nanosecond pulsed electric field ablation of hepatocellular carcinoma.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 6861-5.
2011 Targeted tissue ablation with nanosecond pulses.IEEE transactions on bio-medical engineering.
2010 Apoptosis Initiation and Angiogenesis Inhibition: Melanoma Targets for Nanosecond Pulsed Electric FieldsPigment Cell Melanoma Research. 554.
2010 Bioelectric applications for treatment of melanoma.Cancers. 1731-70.
2010 Cellular apoptosis by nanosecond, high-intensity electric pulses: model evaluation of the pulsing threshold and extrinsic pathway.Bioelectrochemistry (Amsterdam, Netherlands). 179-86.
2010 Dielectrophoretic separation of mouse melanoma clones.Biomicrofluidics.
2010 Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma.Archives of Biochemistry and Biophysics. 82-9.
2009 A Scaling Law for Bioelectric Effects of Nanosecond PulsesIEEE Trans. Dielectr. and Electr. Insula.. 1224-1235.
2009 A new pulsed electric field therapy for melanoma disrupts the tumor’s blood supply and causes complete remission without recurrenceInt J Cancer. 438-45.
2009 A new pulsed electric field therapy for melanoma disrupts tumor's blood supply and causes complete remission without recurrenceInternational Journal of Cancer. 438-445.
2009 Non-ionizing radiation with nanosecond pulsed electric fields as a cancer treatment: in vitro studies.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 6509-12.
2008 Nanosecond Pulse Electric Field (nanopulse): a Novel Non-ligand Agonist for Platelet ActivationArchives of Biochemistry and Biophysics. 240-248.
2008 The Effect of Intense Subnanosecond Electrical Pulses on Biological CellsIEEE Trans. Plasma Science. 414.
2007 Bioelectric Effects of Nanosecond PulsesIEEE Trans. Diel. Electr. Insul.. 1088-1109.
2007 Nanosecond electric pulses penetrate the nucleus and enhance speckle formation.Biochemical and biophysical research communications. 220-5.
2007 Nanosecond pulsed electric fields have differential effects on cells in the S-phase.DNA and cell biology. 160-71.
2007 Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells.Apoptosis : an international journal on programmed cell death. 1721-31.
2007 Simulations of intracellular calcium release dynamics in response to a high-intensity, ultrashort electric pulse.Physical review. E, Statistical, nonlinear, and soft matter physics. 041920.
2007 Ultrashort electric pulse induced changes in cellular dielectric properties.Biochemical and biophysical research communications. 139-44.
2006 Nanosecond pulsed electric fields cause melanomas to self-destruct.Biochemical and biophysical research communications. 351-60.
2006 Plasma membrane voltage changes during nanosecond pulsed electric field exposure.Biophysical Journal. 3608-15.
2005 3,4-Methylendioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cellsCardiovasc Toxicol. 301-310.
2005 3,4-Methylenedioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cellsCardiovascular Toxicology. 301-10.
2005 Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells.DNA and cell biology. 283-91.
2005 Simulations of transient membrane behavior in cells subjected to a high-intensity ultrashort electric pulse.Physical review. E, Statistical, nonlinear, and soft matter physics. 031914.
2004 Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells.Protein expression and purification. 156-69.
2004 Energy-landscape-model analysis for irreversibility and its pulse-width dependence in cells subjected to a high-intensity ultrashort electric pulse.Physical review. E, Statistical, nonlinear, and soft matter physics. 051901.
2004 Leukemic cell intracellular responses to nanosecond electric fields.Biochemical and biophysical research communications. 421-7.
2004 Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms.Physiological measurement. 1077-93.
2004 Somatic cell apoptosis markers and pathways in human ejaculated sperm: potential utility as indicators of sperm quality.Molecular human reproduction. 825-34.
2004 Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields.The Journal of biological chemistry. 22964-72.
2004 Ultrashort electrical pulses open a new gateway into biological cellsProceedings of the Ieee. 1122-1137.
2003 Cocaine but not morphine causes the generation of reactive oxygen species and activation of NF?B in transiently co-transfected heart and renal epithelial cellsCardiovascular Toxicology. 141-151.
2003 Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells.Cardiovascular Toxicology. 141-51.
2003 Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival, DNA damage, and cell cycle analysisMutat Res. 65-75.
2003 Diverse effects of nanosecond pulsed electric fields on cells and tissues.DNA and cell biology. 785-96.
2003 Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1493-5.
2003 The effects of intense submicrosecond electrical pulses on cells.Biophysical Journal. 2709-14.
2002 Differential transcriptional regulation by the alpha- and gamma-catalytic subunit isoforms of cAMP-dependent protein kinase.Archives of Biochemistry and Biophysics. 219-28.
2002 Resveratrol induces apoptosis in LNCaP cells and requires hydroxyl groups to decrease viability in LNCaP and DU 145 cells.The Prostate. 319-29.
2001 Intracellular effect of ultrashort electrical pulses.Bioelectromagnetics. 440-8.
1998 Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3.The Journal of biological chemistry. 6736-43.
1995 Regulation of PDGF-A: a possible mechanism for angiotensin II-induced vascular growth.The American journal of physiology. H356-64.
1994 The cAMP-dependent protein kinases and cAMP signal transduction.Seminars in cancer biology. 285-94.
1993 Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1005-12.
1992 Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13.Cytogenetics and cell genetics. 22-5.
1992 Partial mapping of cyclic nucleotide sites and studies of regulatory mechanisms of phosphodiesterases using cyclic nucleotide analogues.Advances in second messenger and phosphoprotein research. 45-53.
1992 Preclinical models for human pre-embryo biopsy and genetic diagnosis. I. Efficiency and normalcy of mouse pre-embryo development after different biopsy techniques.Fertility and Sterility. 425-30.
1992 Preclinical models for human pre-embryo biopsy and genetic diagnosis. II. Polymerase chain reaction amplification of deoxyribonucleic acid from single lymphoblasts and blastomeres with mutation detection.Fertility and Sterility. 431-8.
1992 Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction.Developmental biology. 48-54.
1992 The C gamma subunit is a unique isozyme of the cAMP-dependent protein kinase.The Journal of biological chemistry. 25505-12.
1991 Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.The Journal of biological chemistry. 18655-9.
1991 Identification, characterization, and hormonal regulation of 3', 5'-cyclic adenosine monophosphate-dependent protein kinases in rat Sertoli cells.Endocrinology. 2345-54.
1990 Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.Oncogene. 1133-9.
1990 Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.Molecular endocrinology (Baltimore, Md.). 465-75.
1990 Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.The Journal of biological chemistry. 1376-80.
1989 Evidence that cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation causes pig ovarian granulosa cell differentiation, including increases in two type II subclasses of this kinase.Biology of reproduction. 295-307.
1988 Biphasic response to 3',5'-cyclic adenosine monophosphate (cAMP) at the messenger ribonucleic acid level for a regulatory subunit of cAMP-dependent protein kinase.Molecular endocrinology (Baltimore, Md.). 1070-6.
1988 Mechanism and function of cAMP- and cGMP-dependent protein kinases.Advances in second messenger and phosphoprotein research. 75-86.
1988 Purification and assay of cAMP, cGMP, and cyclic nucleotide analogs in cells treated with cyclic nucleotide analogs.Methods in enzymology. 74-82.
1988 Use of synergistic pairs of site-selective cAMP analogs in intact cells.Methods in enzymology. 118-39.
1988 cAMP analogs used to study low-Km, hormone-sensitive phosphodiesterase.Methods in enzymology. 531-40.
1987 Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.Molecular endocrinology (Baltimore, Md.). 639-47.
1987 Short-term feedback regulation of cAMP by accelerated degradation in rat tissues.The Journal of biological chemistry. 333-9.
1985 Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.The Journal of biological chemistry. 15781-8.
1985 cAMP-dependent protein kinase activation lowers hepatocyte cAMP.The Journal of biological chemistry. 8731-5.
1984 Microheterogeneity of type II cAMP-dependent protein kinase in various mammalian species and tissues.The Journal of biological chemistry. 10596-605.
1984 Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex.The Journal of biological chemistry. 1415-22.
1984 Rat adipose tissue cAMP-dependent protein kinase: a unique form of type II.Molecular and cellular endocrinology. 67-78.
1984 Two classes of cAMP analogs which are selective for the two different cAMP-binding sites of type II protein kinase demonstrate synergism when added together to intact adipocytes.The Journal of biological chemistry. 3539-47.
1980 Isolation and characterization of cyclic AMP-independent glycogen synthase kinase from rat skeletal muscle.Biochimica et biophysica acta. 324-40.

Education And Training

  • Ph.D. in Medical Sciences/Pharmacology, Medical College Of Ohio 1982
  • Full Name

  • Stephen Beebe