Overview

  • Grew up in Bristol, VA. Educated and employed by the University of Virgina for over 40 years.
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 Electrospun silk-collagen scaffolds and BMP-13 for ligament and tendon repair and regenerationBiomedical Physics & Engineering Express. 1-14.
    2018 Epigenetic alterations mediate iPSC normalization of DNA-repair expression and TNR stability in Huntington's disease.Journal of cell science.
    2017 Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors.Stem cells international. 1513281.
    2016 Accessible bioprinting: adaptation of a low-cost 3D-printer for precise cell placement and stem cell differentiation.Biofabrication. 025017.
    2016 DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells.The American journal of pathology. 1967-76.
    2015 A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction.Physiological Reports.
    2015 Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras.Biomaterials. 98-107.
    2012 Local Delivery of FTY720 Accelerates Cranial Allograft Incorporation and Bone FormationCell Tiss. Res.. 553-566.
    2011 Alignment and composition of laminin-polycaprolactone nanofiber blends enhance peripheral nerve regeneration.Journal of biomedical materials research. Part A.
    2011 Expression of transforming growth factor-?-responsive smads in cranial suture development and closure.The Journal of craniofacial surgery. 324-8.
    2010 FTY720 promotes local microvascular network formation and regeneration of cranial bone defects.Tissue engineering. Part A. 1801-9.
    2010 Injectable tissue-engineered bone repair of a rat calvarial defect.The Laryngoscope. 895-901.
    2009 Adipose stem cells and solid organ transplantation.Current opinion in organ transplantation. 51-5.
    2009 Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds.Journal of biomedical materials research. Part A. 632-41.
    2009 Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes.Tissue engineering. Part C, Methods. 11-21.
    2008 Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells.Journal of tissue engineering and regenerative medicine. 210-20.
    2008 Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(epsilon-caprolactone) fabricated via co-extrusion and gas foaming.Acta Biomaterialia. 1187-97.
    2007 Application of cyclic tensional forces influence gene expression and sutural state of rat calvariae in vitro.Plastic and reconstructive surgery. 601.
    2007 Cellular dynamics and tissue interactions of the dura mater during head development.Birth defects research. Part C, Embryo today : reviews. 297-304.
    2006 Adipose tissue: stem cells and beyond.Clinics in plastic surgery. 55-62, vi.
    2005 Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells.Stem cells (Dayton, Ohio). 412-23.
    2005 Morphology, growth and developmental plasticity of human adipocytes.Annals of plastic surgery. 651-6.
    2004 Aberrant bony vasculature associated with activating fibroblast growth factor receptor mutations accompanying Crouzon syndrome.The Journal of craniofacial surgery. 431.
    2004 BMP-9-transduced prefabricated muscular flaps for the treatment of bony defects.The Journal of craniofacial surgery. 736.
    2004 Ex vivo fat graft preservation: effects and implications of cryopreservation.Annals of plastic surgery. 281-2; discussion 283.
    2004 Regulation of cranial suture morphogenesis.Cells, tissues, organs. 54-66.
    2003 Human adipocyte viability testing: a new assay.Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery. 265-9.
    2003 Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. 398-402.
    2001 Correction of coronal suture synostosis using suture and dura mater allografts in rabbits with familial craniosynostosis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 206-25.
    2000 Craniofacial skeletal morphogenesis in vitro.Methods in molecular biology (Clifton, N.J.). 55-9.
    1999 Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro.Journal of craniofacial genetics and developmental biology. 164-73.
    1999 Insulinlike growth factor 1- and 2-augmented collagen gel repair of facial osseous defects.Archives of otolaryngology--head & neck surgery. 451-5.
    1999 Repair of a rodent nasal critical-size osseous defect with osteoblast augmented collagen gel.The Laryngoscope. 1580-4.
    1999 Repair of an osseous facial critical-size defect using augmented fibrin sealant.The Laryngoscope. 1585-8.
    1998 Dura mater maintains rat cranial sutures in vitro by regulating suture cell proliferation and collagen production.Journal of craniofacial genetics and developmental biology. 150-8.
    1998 Repair of nasal defects using collagen gels containing insulin-like growth factor 1.The Laryngoscope. 1654-8.
    1997 Elevated levels of transforming growth factors beta 2 and beta 3 in lambdoid sutures from children with persistent plagiocephaly.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 331-7.
    1997 Laminin E8 alveolarization site: heparin sensitivity, cell surface receptors, and role in cell spreading.The American journal of physiology. L494-503.
    1997 TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 301-10.
    1996 Altered production of laminin and nidogen by high and low metastatic variants of murine melanoma cells.Oncology research. 131-8.
    1996 Nasal reconstruction using an osteoconductive collagen gel matrix.Archives of otolaryngology--head & neck surgery. 37-40.
    1995 A rapid in vitro assay of cellular chemomigration in an epithelial carcinoma cell line.Plastic and reconstructive surgery. 1689-93.
    1995 Cranial sutures require tissue interactions with dura mater to resist osseous obliteration in vitro.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1978-87.
    1995 Laminin and Fibronectin Content of Mouse Glomerular and Tubular Basement MembraneKidney and Blood Pressure Research. 1-11.
    1995 Repair of critical size rat calvarial defects using extracellular matrix protein gels.Journal of neurosurgery. 710-5.
    1994 In the absence of periosteum, transplanted fetal and neonatal rat coronal sutures resist osseous obliteration.The Journal of craniofacial surgery. 327-32.
    1993 Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications.The Journal of craniofacial surgery. 85-9; discussion 90.
    1993 Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures.Developmental dynamics : an official publication of the American Association of Anatomists. 312-22.
    1990 Laminin potentiates differentiation of PCC4uva embryonal carcinoma into neurons.Journal of cell science. 23-31.
    1989 Collagen binding proteins derived from the embryonic fibroblast cell surface recognize arginine-glycine-aspartic acidBioscience Reports. 329-340.
    1989 Embryonic chicken fibroblast collagen binding proteins: distribution, role in substratum adhesion, and relationship to integrins.Journal of cell science. 361-9.
    1989 Embryonic heart mesenchymal cell migration in laminin.Developmental biology. 37-43.
    1989 The in vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants.Clinical & experimental metastasis. 437-51.
    1988 Laminin receptors for neurite formationProc. Natl. Acad. Sci. USA. 1282-1286.
    1988 Response properties of primary olfactory neurons from the lobster: Tuning of hydroxy-proline sensitive cellsJ. Comp. Phys.. 201-211.
    1988 The characterization of ribosomal RNA gene chromatin from Physarum polycephalum.The Journal of biological chemistry. 10734-44.
    1988 The purification of ribosomal RNA gene chromatin from Physarum polycephalum.The Journal of biological chemistry. 10725-33.
    1987 A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor.Biochemistry. 6896-900.
    1987 Role of basement membranes in cell differentiation.Annals of the New York Academy of Sciences. 134-45.
    1986 Collagen binding proteins associated with the chicken embryonic cell surfaceProgress in Clinical & Biological Research. 173-176.
    1983 Structure and biosynthesis of collagen in skeletal tissuesConnect. Tiss. Res.. 234-235.
    1974 Aryl sulfatase activities in normal and pathologic human articular cartilage.Arthritis and Rheumatism. 455-67.

    Research Overview

  • Regenerative medicine. Stem cell biology and therapy. Tissue engineering. Models for genetic disease. Biotechnology.
  • Grants

  • Therapeutic S1P Drug Targets for Cranial Bone Repair  awarded by NIH, NIAMS 2009 - 2014
  • Development of Human Adipose Stem Cells and Anti-inflammatory Drugs in ALS Therapy.  awarded by Virginia Gentleman Foundation 2010 - 2013
  • Drug Recruitment of endogenous Stem Cells during Cranial Bone Repair  awarded by DOD 2010 - 2013
  • Peer Review orthopedic research program, Novel Bioactive Coatings to Improve Allograft Incorporation  awarded by DOD 2010 - 2013
  • Vascularized Bone Grafts for Tissue Engineering  awarded by NIH 2008 - 2013
  • Systems for Peripheral Nerve Repair  awarded by NSF EFRI ( U. Conn, and UVA) 2008 - 2011
  • Production of EHS Tumor, Laminin and Reconstituted Basement Membrane  awarded by Stemgent 2008 - 2009
  • The Adaptosome, a Nanoscale Delivery System for Specific Cell Targeting  awarded by UVA NanoStar Seed Grant 2008 - 2009
  • Cranial Bone Repair with Adipose-Derived Stem Cells  awarded by NIH R21 DE15023-02 2002 - 2005
  • Regulation of Cranial Suture Morphogenesis  awarded by NIH, 1 RO1 DE 10369-09 1994 - 2005
  • Regeneration of Calvarial Defects with Adipose-Derived Stem Cells  awarded by Plastic Surgery Educational Foundation 2002 - 2003
  • A Rat Model of the Developing Sagittal Suture  awarded by Plastic Surgery Education Foundation 2001 - 2002
  • Human Adipocytes in Fat Grafting Techniques  awarded by Aesthetic Surgery Education and Research Foundation 2001 - 2002
  • Quantification of Force Induces Cranial Suture Fusion in a Rat Model  awarded by Maxillofacial Surgeons Foundation 2001 - 2002
  • Growth Factor Regulation of Cranial Suture Morphogenesis  awarded by NIH 1996 - 2001
  • Tissue Engineering of Auricular Cartilage, Research and Development Grant  awarded by University of Virginia Medical Center 1998 - 2000
  • Tissue Engineering of Auricular Cartilage, Young Investator Grant  awarded by American Academy of Facial Plastic and Reconstructive Surgery 1998 - 2000
  • Fibroblast Growth Factor Signaling in Cracial Suture Cells  awarded by Plastic Surgery Education Foundation 1997 - 1998
  • Coronal Suture Transplant in Rabbits with Congenital Craniosynostosis  awarded by March of Dimes 1995 - 1997
  • Repair of Bone with Extracellular Matrix  awarded by NIH 1994 - 1997
  • Growth Factors in Human Hemangiomas  awarded by Plastic Surgery Education Foundation 1994 - 1995
  • Skull Development in vitro  awarded by Maxillofacial Surgeons Foundation 1994 - 1995
  • Molecular Analysis of Abnormalities Associated with Craniosynostosis  awarded by Plastic Surgery Education Foundation, Faculty Sponsor for T. Gampper 1993 - 1995
  • Metastasis-Associate Integrins  awarded by American Cancer Society CB-37A 1992 - 1995
  • In Vitro Definition of Cellular Abnormalities Associated with Craniosynostosis  awarded by Maxillofacial Surgeons Foundation 1993 - 1994
  • Repair of Bone with Collagen Gels and Osteoblasts, Faculty Sponsor for T. M. Sweeney  awarded by Orthopedic Research and Education Foundation 1993 - 1994
  • An In Vitro model of Metastasis for Squamous Cell Carcinoma  awarded by Plastic Surgery Education Foundation, Faculty Sponsor for Edward Ricciardelli 1992 - 1993
  • Repair of Bone Defects with Extracellular Matrix Gels  awarded by Plastic Surgery Education Foundation, Faculty Sponsor for T.M. Sweeney 1992 - 1993
  • The Role of Basement Membranes in Osteogenesis  awarded by Jeffress Memorial Trust 1991 - 1993
  • Basement Membranes of Hemangioma Endothelial Cells  awarded by Plastic Surgery Education Foundation, Faculty Sponsor to D. Wang 1991 - 1992
  • Cellular biology of Craniofacial Intramembranous Ossification  awarded by Plastic Surgery Educatin Foundation 1991 - 1992
  • The Sutural/Dural Interrelationship in Maintaining Sutural Patency During Development of the Skull  awarded by Maxillofacial Surgeons Foundations 1991 - 1992
  • Metastasis-Associated Integrins  awarded by American Cancer Society Institutional, UVa 1991
  • Struture, Function, and Expression of Basement Membrane Receptors in the Embryo  awarded by March of Dimes Basil O'Connor Award 1988 - 1991
  • Cellular and Molecular Biology of Cardiac Morphogenesis  awarded by NIH 1986 - 1991
  • The Role of Laminin and its Receptor in Cardiac Endothelial Cell Differentiation  awarded by American Heart Association 1988 - 1990
  • Adhesion of Metastatic Melanoma Cells to Collagen IV  awarded by American Cancer Society Institutional Award, MUSC 1988 - 1989
  • National Research Service Award (Predoctoral)  awarded by NIH 1984 - 1985
  • Characterization of Collagen and Laminin Receptors  awarded by Upjohn 1986 -
  • Education And Training

  • Ph.D. in Cell and Molecular Biology, University of Virginia 1985
  • B.A. in Biology, University of Virginia 1972
  • Full Name

  • Roy Ogle