Overview

  • Dr. Sachs received his Ph.D. from the Medical College of Virginia in the Department of Human and Molecular Genetics, where he studied adult and pluripotent stem cell biology specifically related to the regulation of the enzyme telomerase. In his post-doctoral work, he studied the heterotypic interactions of breast cancer cells with adult stem cells in a mouse model. As a scientist for LifeNet Health, Patrick led efforts to generate pluripotent stem cells from normal and diseased donor cells and expanded LifeNet’s tissue engineering capabilities to include cell-centric grafts and therapies. At ODU Dr. Sachs studies the biology of stem cells, regenerative medicine, tissue engineering, cancer biology and neurobiology
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 3D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells.Journal of neural engineering. 056021.
    2018 ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis.Pathology. 524-529.
    2018 Epigenetic alterations mediate iPSC normalization of DNA-repair expression and TNR stability in Huntington's diseaseJournal of Cell Science.
    2017 Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors.Stem cells international. 1513281.
    2017 Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicineJournal of Biological Engineering. 1-11.
    2016 Accessible bioprinting: adaptation of a low-cost 3D-printer for precise cell placement and stem cell differentiation.Biofabrication. 025017.
    2016 DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells.The American journal of pathology.
    2012 Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites.Cell and tissue research. 505-15.
    2012 Electrospinning adipose tissue-derived extracellular matrix for adipose stem cell culture.Journal of biomedical materials research. Part A. 1716-24.
    2012 Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type.Cancer biology & therapy. 782-92.
    2010 Isolating adipose-derived mesenchymal stem cells from lipoaspirate blood and saline fraction.Organogenesis. 11-4.
    2009 Genetic inhibition of telomerase results in sensitization and recovery of breast tumor cells.Molecular cancer therapeutics. 1319-27.

    Chapters

    Year Title
    2009 Regulation of Telomerase Through Transcriptional and Post-translational MechanismsTelomeres and telomerase in cancer.

    Research Overview

  • The Sachs lab focuses on the study of techniques and technologies for elongating human lifespan. Many of these regenerative medicine/tissue engineering techniques revolve around the regulation of the enzyme telomerase, the induction of pluripotency in normal somatic cells (iPSC) and the stem cell niche.
  • Keywords

  • Biotechnology : Tissue Engineering, Regenerative Medicine, Neurobiology, Stem Cell Biology, Cancer Biology
  • Education And Training

  • Ph.D. in Human and Molecular Genetics, Medical College of Virginia 2010
  • B.S. in Biology, Virginia Commonwealth University 2002
  • Full Name

  • Patrick Sachs