Overview

  • Veterinary Medicine Faculty of the Agricultural Academy in Lublin, Poland, D.V.M., 1987Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Poland, Ph.D., 1995
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.Biochimica et biophysica acta. 40-50.
    2017 Coordination of different complexes to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytesBiochimica et biophysica acta.
    2017 The mechanisms shaping the repertoire of CD4+ Foxp3+ Treg cellsImmunology.
    2015 Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophagesDisease Models and Mechanisms. 691-700.
    2014 MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axisJ Autoimmun. 95-104.
    2014 Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapyJ Immunotoxicol. 319-27.
    2013 SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responsesAm J Transl Res. 427-40.
    2013 Systematic evaluation of 640 FDA drugs for their effect on CD4(+)Foxp3(+) regulatory T cells using a novel cell-based high throughput screening assayBiochem Pharmacol. 1513-24.
    2013 Thymus-derived regulatory T cells contribute to tolerance to commensal microbiotaNature. 258-62.
    2011 Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cellsJ Immunol. 248-57.
    2010 Intratumoral convergence of the TCR repertoires of effector and Foxp3+ CD4+ T cellsPLOS ONE. e13623.
    2009 Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subsetJ Immunol. 3731-41.
    2009 TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cellsJ Immunol. 3118-29.
    2008 ParaKMeans: Implementation of a parallelized K-means algorithm suitable for general laboratory useBMC Bioinformatics. 200.
    2007 Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cellsImmunity. 493-504.
    2006 Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cellsImmunity. 249-59.
    2005 caBIONet–A .NET wrapper to access and process genomic data stored at the National Cancer Institute’s Center for Bioinformatics databasesBioinformatics. 3456-8.
    2002 Peptide specificity of thymic selection of CD4+CD25+ T cellsJ Immunol. 613-20.
    2002 Positive selection of a Qa-1-restricted T cell receptor with specificity for insulinImmunity. 95-105.
    2002 Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cellsProc Natl Acad Sci U S A. 15012-7.
    2001 Alpha beta TCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligandJ Immunol. 2251-9.
    2001 An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected alpha beta TCRsJ Immunol. 2357-63.
    2001 Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptidesJ Exp Med. 407-16.
    2000 Altered selection of CD4+ T cells by class II MHC bound with dominant and low abundance self-peptidesJ Immunol. 6099-106.
    1997 Factors influencing the preimmune antibody repertoireFolia Biol (Praha). 53-61.
    1997 The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cellsJ Immunol. 5824-32.
    1995 Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoireJ Immunol. 6406-20.
    1995 Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myelomaClin Diagn Lab Immunol. 44-52.
    1995 VH4.21 expression in the normal human B-cell repertoireAnn N Y Acad Sci. 285-92.

    Research Overview

  • My research is focused on uncovering cellular and molecular mechanisms of immune system with special emphasis on processes that regulate the development and functions of conventional and regulatory T cells. I am interested in how immune tolerance is established and preserved in healthy individuals and how tolerance mechanisms are subverted or alleviated to permit growth of tumor cells. The aim of ongoing, NIH funded projects is to reveal how inflammation associated with tumor growth modulates T cell functions in tumors. In particular, we investigate the involvement of connexin 43 and Bone Morphogenic Protein Receptor 1α in the generation of regulatory CD4+ T cells in the thymus and in the interplay between stromal cells and components of the innate and adaptive immune system in a mouse model of prostate cancer. The goal of our studies is to reveal and exploit novel mechanisms of immune regulation to overcome challenges facing immunotherapies of cancer.
  • Expertise Keywords

  • Cancer : Cancer Immunology
  • Research : Genomics and proteomics
  • Research : Immunology
  • Education And Training

  • Ph.D. in Immunology & Experimental Therapy, Polish Academy of Sciences 1995
  • Full Name

  • Piotr Kraj