The current research is centered on understanding and characterization of cell response to pulsed electric fields treatments, with particular emphasis on nanosecond-duration pulses and cell death mechanisms.Main topics of the research include:1) mechanisms of the PEF-triggered cell death, characterization of the cell death pathways2) escalation of cell sensitivity to pulsed electric field (PEF) for advancement of PEF-mediated tissue and tumor ablation3) PEF-induced communication between the cells