Selected Publications

Articles In Academic Journals

Year Title
2016 Elucidating the Key Determinants of Structure, Folding, and Stability for the (4 beta-alpha) Conformation of the B1 Domain of Protein G Using Bioinformatics ApproachesIEEE transactions on nanobioscience.
2012 Biophysical analysis of the transition of an all ?-helical Greek-key protein into amyloid fibrils composed of ?-sheet structureProtein and peptide letters. 982-90.
2012 Folding of an all-helical Greek-key protein monitored by quenched-flow hydrogen-deuterium exchange and NMR spectroscopyEuropean biophysics journal (EBJ). 41-51.
2012 Protein folding by 'levels of separation': a hypothesisFEBS letters. 962-6.
2012 Protein structure networksBriefings in functional genomics. 469-78.
2010 Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-bindingPLOS ONE. e8654.
2009 Analysis of conservation in the Fas-associated death domain protein and the importance of conserved tryptophans in structure, stability, and foldingBiochmica et Biophysica Acta - Proteins & Proteomics. 583-593.
2009 Probing the urea dependence of nonrandom interactions in denatured human ?-lactalbuminJ. Biomolecular NMR. 121-131.
2009 The CATH hierarchy revisited - structural divergence in domain superfamilies and the continuity of fold spaceStructure. 1051-1062.
2007 The CATh domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolutionNucleic acids research. D291-D297.
2006 Characterization of the molten globule of human-serum retinol-binding protein by NMR spectroscopyBiochemistry. 9475-9484.
2006 Elucidation of conserved long-range interaction networks in proteins and their significance in determining protein topologyPhysica A. 595-606.
2005 Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approachFEBS J. 4826-4838.
2005 Conserved networks and the determinants of protein topologyFEBS J. Suppl. 1.
2005 Quantitation of protein expression in a cell-free system: Efficient detection of yields and 19F NMR to identify folded proteinJ Biomolecular NMR. 11-19.
2003 Conserved signature proposed for folding in the lipocalin superfamilyFEBS letters. 39-44.
2003 Uncovering network systems within protein structuresJournal of molecular biology. 781-91.
2002 Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometryStructure (London, England : 1993). 851-63.
2001 Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamilyProtein science : a publication of the Protein Society. 2301-16.
1999 Stability, activity and flexibility in alpha-lactalbuminProtein engineering. 581-7.


Year Title
2013 Conversion of all ?-helical proteins into an alternative ?-amyloid conformationBio-nanoimaging – Protein Misfolding and Aggregation.. Academic Press.
2006 The lipocalin protein family: Protein sequence and structureLipocalins. Georgetown, TX: Landes Biosciences and

Conference Papers

Year Title
2018 Demonstration of horizontal gene transfer from genetically engineered cyanobacteria to wild-type E. coli
2011 Potential Application of Cold Plasma in Neurodegenerative Diseases associated with Amyloid Fibrils

Research Overview

  • 1. Protein Chemistry2. Molecular Biology and Genetic Engineering3. Bioinformatics and Genomics4. Protein Evolution5. Biophysics: Multidimensional heteronuclear NMR, Real-time 1D NMR & Photo-CIDNP, Circular dichroism & Fluorescence spectroscopy (equilibrium & stopped flow); Quenched flow HX.
  • Grants

  • Designer Algae Biotechnology Risk Assessment  awarded by USDA/NIFA Grant Award Number: 2016-33522-25624 2016 - 2019
  • Exploratory Look into the Future: Investigation Adaptation  awarded by Virginia Academy of Science 2017 - 2018
  • An integrative approach to teaching undergraduate genetics and biochemistry  awarded by ODU CLT 2017
  • Vas Chrctztn Wheat Lipcln Vari 2014 - 2015
  • Jeffress Grant  awarded by Jeffress Memorial Trust (Renewal) 2009 - 2010
  • SEECR Grant  awarded by Old Dominion University 2009
  • Elucidation of protein structure networks and beyond  awarded by ODU-RF 2008
  • Jeffress Grant  awarded by Jeffress Memorial Trust 2008
  • Multidisciplinary Grant  awarded by Old Dominion University 2008
  • Faculty Research Fellowship  awarded by Old Dominion University 2007
  • Engineering and Physical Sciences Research Council Grant (U.K.) 2002 - 2005
  • Biotechnology and Biological Sciences Research Council Grant (U.K.) 2002 - 2004
  • Lockey Bequest Travel Awards  awarded by University of Oxford 2002
  • International Research Fellows Award  awarded by National Science Foundation 2000 - 2002
  • Lockey Bequest Travel Awards  awarded by University of Oxford 2000
  • Exploratory look into the future: Investigating adaption and evolution of Synechococcus in response to high CO2 at the genomic-level  awarded by Virginia Academy of Sciences 2017 -
  • PURS  awarded by ODU 2016 -
  • An Online Tacit Knowledge-Transferring Tool for Novice Science Teachers Who Teach Students with Disabilities  awarded by National Science Foundation 2000 -
  • An Online Tacit Knowledge-Transferring Tool for Novice Science Teachers Who Teach Students with Disabilities  awarded by National Science Foundation 1990 -
  • Expertise Keywords

  • Chemistry : Protein Biochemistry, Bioinformatics, Genetics
  • Education And Training

  • Ph.D. in Biochemistry, University of Miami 1998
  • B.S. in Microbiology, University of Miami 1991
  • Full Name

  • Lesley Greene