• Grew up in Ohio, PhD at University of Missouri, Washington University Postdoc. At Wistar Institute in Philadelphia for 25 years, joined ODU in 2015. Telomere biology, genomics, and translational science.
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2017 A Neighborhood-Wide Association Study (NWAS): Example of prostate cancer aggressivenessPLOS ONE. 1-13.
    2017 High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres.Nucleic acids research. e73.
    2016 CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis.Nucleic acids research. e11.
    2016 Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.Genome biology. 158.
    2016 Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.The EMBO journal. 193-207.
    2015 Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.Nature communications. 7505.
    2014 Functional characterization of the TERRA transcriptome at damaged telomeres.Nature communications. 5379.
    2014 Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline.Genome research. 1039-50.
    2012 A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection.The EMBO journal. 4165-78.
    2011 Molecular analysis of ring chromosome 20 syndrome reveals two distinct groups of patients.Journal of medical genetics. 1-9.
    2010 Two siblings with alternate unbalanced recombinants derived from a large cryptic maternal pericentric inversion of chromosome 20.American journal of medical genetics. Part A. 373-82.
    2009 Correlation of telomere length and telomerase activity with occult ovarian insufficiency.The Journal of clinical endocrinology and metabolism. 4835-43.
    2009 TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.Molecular cell. 403-13.
    2009 Telomere length regulates ISG15 expression in human cells.Aging. 608-21.
    2008 Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome.Genome biology. R155.
    2008 Fine-mapping subtelomeric deletions and duplications by comparative genomic hybridization in 42 individuals.American journal of medical genetics. Part A. 730-9.
    2008 Human subtelomeric copy number variations.Cytogenetic and genome research. 244-52.
    2008 Human telomere structure and biology.Annual review of genomics and human genetics. 1-19.
    2007 Human subtelomeric duplicon structure and organization.Genome biology. R151.
    2005 Human subtelomere structure and variation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 505-15.
    2004 Genome sequence of the Brown Norway rat yields insights into mammalian evolution.Nature. 493-521.
    2004 Mapping and initial analysis of human subtelomeric sequence assemblies.Genome research. 18-28.
    2003 Human subtelomeric DNA.Cold Spring Harbor symposia on quantitative biology. 39-47.
    2003 Telomere length and the expression of natural telomeric genes in human fibroblasts.Human molecular genetics. 1329-36.
    2001 A sequence-ready map of the human chromosome 1q telomere.Genomics. 105-7.
    2001 Integration of telomere sequences with the draft human genome sequence.Nature. 948-51.
    2000 An optimized set of human telomere clones for studying telomere integrity and architecture.American journal of human genetics. 320-32.
    1999 A sequence-ready map of the human chromosome 17p telomere.Genomics. 207-10.
    1999 Characterization of physical gap sizes at human telomeres.Genome research. 888-94.
    1997 Closing in on telomeric closure.Genome research. 853-5.
    1996 A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere.Genomics. 353-60.
    1996 The Bin1 Gene Localizes to Human Chromosome 2q14 by PCR Analysis of Somatic Cell Hybrids and Fluorescence in Situ HybridizationGenomics. 329-31.
    1995 A complete map of the human immunoglobulin VH locus.Annals of the New York Academy of Sciences. 43-6.
    1995 Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcoma.Genomics. 1-8.
    1995 Molecular cloning and RARE cleavage mapping of human 2p, 6q, 8q, 12q, and 18q telomeres.Genome research. 225-32.
    1995 Structure of the terminal 300 kb of DNA from human chromosome 21q.Genomics. 31-8.
    1994 A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.Nature genetics. 162-8.
    1994 Interstitial deletions are not the main mechanism leading to 18q deletions.American journal of human genetics. 1085-91.
    1994 Mapping vector-adjacent DNA from a 7q human telomeric YAC using RARE.Mammalian genome : official journal of the International Mammalian Genome Society. 596.
    1994 Physical analysis of the terminal 270 kb of DNA from human chromosome 1q.Genomics. 569-78.
    1994 Sequence organization of the human chromosome 2q telomere.Human molecular genetics. 1847-53.
    1993 A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones.Human genetics. 527-32.
    1993 Chromosomal bar codes produced by multicolor fluorescence in situ hybridization with multiple YAC clones and whole chromosome painting probes.Human molecular genetics. 505-12.
    1993 Physical analysis of the terminal 240 kb of DNA from human chromosome 7q.Genomics. 25-32.
    1992 Closure of a genetic linkage map of human chromosome 7q with centromere and telomere polymorphisms.Genomics. 1041-54.
    1992 Direct DNA hybridization screening of primary yeast transformants in the construction of targeted yeast artificial chromosome (YAC) libraries.Genetic analysis, techniques and applications. 58-63.
    1992 Metaphase and interphase cytogenetics with Alu-PCR-amplified yeast artificial chromosome clones containing the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erbB-2.Cancer research. 2590-6.
    1991 Detection and characterization of chimeric yeast artificial-chromosome clones.Genomics. 658-69.
    1990 Characterization of polymorphic loci on a telomeric fragment of DNA from the long arm of human chromosome 7.Genomics. 168-70.
    1990 Painting of human chromosomes with probes generated from hybrid cell lines by PCR with Alu and L1 primers.Human genetics. 1-6.
    1989 Cloning human telomeric DNA fragments into Saccharomyces cerevisiae using a yeast-artificial-chromosome vector.Proceedings of the National Academy of Sciences of the United States of America. 6240-4.
    1988 Characterization of phycobilisome glycoproteins in the cyanobacterium Anacystis nidulans R2.Journal of bacteriology. 2433-40.
    1988 Immunological Characterization of Iron-Regulated Membrane Proteins in the Cyanobacterium Anacystis nidulans R2.Plant physiology. 497-505.
    1988 Purification and characterization of an iron stress-induced chlorophyll-protein from the cyanobacterium Anacystis nidulans R2.Biochimica et biophysica acta. 141-51.
    1988 Regulation of cyanobacterial pigment-protein composition and organization by environmental factors.Photosynthesis research. 133-61.
    1987 Isolation and Characterization of a Carotenoid-Associated Thylakoid Protein from the Cyanobacterium Anacystis nidulans R2.Plant physiology. 633-9.
    1987 Phycobilisome-associated glycoproteins in the cyanobacterium Anacystis nidulans R 2.FEBS letters. 209-14.
    1987 Triton X-114 phase fractionation of an integral membrane surface protein mediating monoclonal antibody killing of Mycoplasma hyorhinis.Infection and immunity. 1094-100.
    1985 Organization of pigment proteins in the photosystem II complex of the cyanobacterium Anacystis nidulans R2.Proceedings of the National Academy of Sciences of the United States of America. 6903-7.
    1985 Organization of the thylakoid membrane from the heterotrophic cyanobacterium, Aphanocapsa 6714.Biochimica et biophysica acta. 148-57.

    Research Overview

  • Translational genomics of human telomeres in cancer, aging, and regenerative medicine; novel telomere-associated biomarkers.
  • Expertise Keywords

  • Biology : Genomics, Cancer, Regenerative Medicine, Telomeres
  • Full Name

  • Harold Riethman