Overview

  • BS and MS from Bangalore University, India in Microbiology and PhD in Microbial Genetics and Genomics from University of Cologne, Germany. Postdoctoral training at Yale University School of Medicine, USA.
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.Biochimica et biophysica acta. 40-50.
    2018 Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cellsPLoS pathogens. e1006764.
    2017 Coordination of different complexes to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytesBiochimica et biophysica acta.
    2017 Human rickettsial pathogen modulates arthropod organic anion transporting polypeptide and tryptophan pathway for its survival in ticksScientific Reports. 1-13.
    2017 Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick ornithodoros turicataInsect Molecular Biology. 1-11.
    2016 An in vitro blood-feeding method revealed differential Borrelia turicatae (Spirochaetales: Spirochaetaceae) gene expression after spirochete acquisition and colonization in the soft tick Ornithodoros turicata (Acari: Argasidae)J Med Entomol. 1-9.
    2016 Molecular identification and bioinformatics analysis of a potential anti-vector vaccine candidate, 15-kDa salivary gland protein (Salp15), from Ixodes affinis ticks.Ticks and Tick-borne Diseases.
    2016 Viral receptors of the gut: vector-borne viruses of medical importance.Current opinion in insect science. 44-50.
    2015 Identification and comparative analysis of subolesin/akirin ortholog from Ornithodoros turicata ticks.Parasites & vectors. 132.
    2015 Transmission-Blocking Vaccines: Focus on Anti-Vector Vaccines against Tick-Borne Diseases.Archivum immunologiae et therapiae experimentalis. 169-79.
    2014 Antivirulence properties of an antifreeze protein.Cell reports. 417-24.
    2013 The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts.Microbes and infection / Institut Pasteur. 729-37.
    2012 Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi.BMC microbiology. 44.
    2012 Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cells.BMC developmental biology. 3.
    2012 Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster.PLoS One. e33447.
    2012 Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-?1/Smad6 signaling.Journal of immunology (Baltimore, Md. : 1950). 3150-8.
    2012 Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-beta1/Smad6 signalingJ Immunol. 3150-8.
    2010 Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold.The Journal of clinical investigation. 3179-90.
    2010 Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks.The Journal of experimental medicine. 1727-43.
    2009 Characterization of a beta-glucoside operon (bgc) prevalent in septicemic and uropathogenic Escherichia coli strains.Applied and Environmental Microbiology. 2284-93.
    2009 Fate of the H-NS-repressed bgl operon in evolution of Escherichia coli.Plos Genetics. e1000405.
    2009 Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody.Journal of immunology (Baltimore, Md. : 1950). 650-60.
    2009 Microarray phenotyping places cyclase associated protein CAP at the crossroad of signaling pathways reorganizing the actin cytoskeleton in Dictyostelium.Experimental Cell Research. 127-40.
    2009 Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks.The Journal of infectious diseases. 1331-40.
    2008 A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks.The Journal of infectious diseases. 148-55.
    2007 Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks.PLoS pathogens. e33.
    2007 Role of outer surface protein D in the Borrelia burgdorferi life cycle.Infection and immunity. 4237-44.
    2005 Genome variations in commensal and pathogenic E. coli.Thesis, University of Cologne, Germany.
    2002 Oxidative cleavage of DNA by a dipyridoquinoxaline copper(II) complex in the presence of ascorbic acid.Journal of Inorganic Biochemistry. 191-6.
    2002 Syntheses, Crystal Structyure, and Nuclease activity of Oxalato-Bridged Dicopper (II) complexes with Planar N-Donor Heterocyclic bases.Eur J Inorg Chem.

    Research Overview

  • Vector-borne diseases, Microbial pathogenesis, Infectious diseases, host-pathogen interaction, Vector biology
  • Keywords

  • Insects : cold tolerance and adaptation in arthropods, Gene regulation, Arthropod physiology, genomics,
  • Microbiology : Infectious diseases, Vector-borne diseases, microbial pathogenesis, host-pathogen interctions, symbiosis, microbial genetics and genomics,
  • Education And Training

  • Ph.D. in Microbial Genetics & Genomics, University of Cologne 2005
  • Full Name

  • Girish Neelakanta