Overview

  • BS and MS from Bangalore University, India in Microbiology and PhD in Microbial Genetics and Genomics from University of Cologne, Germany. Postdoctoral training at Yale University School of Medicine, USA.
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.Biochimica et biophysica acta. 40-50.
    2018 Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cellsPLoS pathogens. e1006764.
    2017 Coordination of different complexes to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytesBiochimica et biophysica acta.
    2017 Human rickettsial pathogen modulates arthropod organic anion transporting polypeptide and tryptophan pathway for its survival in ticksScientific Reports. 1-13.
    2017 Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick ornithodoros turicataInsect Molecular Biology. 1-11.
    2016 An in vitro blood-feeding method revealed differential Borrelia turicatae (Spirochaetales: Spirochaetaceae) gene expression after spirochete acquisition and colonization in the soft tick Ornithodoros turicata (Acari: Argasidae)J Med Entomol. 1-9.
    2016 Molecular identification and bioinformatics analysis of a potential anti-vector vaccine candidate, 15-kDa salivary gland protein (Salp15), from Ixodes affinis ticksTicks and tick-borne diseases.
    2016 Viral receptors of the gut: vector-borne viruses of medical importanceCurrent opinion in insect science. 44-50.
    2015 Identification and comparative analysis of subolesin/akirin ortholog from Ornithodoros turicata ticksParasites & vectors. 132.
    2015 Transmission-Blocking Vaccines: Focus on Anti-Vector Vaccines against Tick-Borne DiseasesArchivum immunologiae et therapiae experimentalis. 169-79.
    2014 Antivirulence properties of an antifreeze proteinCell reports. 417-24.
    2013 The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hostsMicrobes and infection / Institut Pasteur. 729-37.
    2012 Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferiBMC microbiology. 44.
    2012 Ectopic expression of cyclase associated protein CAP restores the streaming and aggregation defects of adenylyl cyclase a deficient Dictyostelium discoideum cellsBMC developmental biology. 3.
    2012 Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogasterPLOS ONE. e33447.
    2012 Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-?1/Smad6 signalingJournal of immunology (Baltimore, Md. : 1950). 3150-8.
    2012 Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-beta1/Smad6 signalingJ Immunol. 3150-8.
    2010 Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the coldThe Journal of clinical investigation. 3179-90.
    2010 Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticksThe Journal of experimental medicine. 1727-43.
    2009 Characterization of a beta-glucoside operon (bgc) prevalent in septicemic and uropathogenic Escherichia coli strainsApplied and Environmental Microbiology. 2284-93.
    2009 Fate of the H-NS-repressed bgl operon in evolution of Escherichia coliPLoS genetics. e1000405.
    2009 Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibodyJournal of immunology (Baltimore, Md. : 1950). 650-60.
    2009 Microarray phenotyping places cyclase associated protein CAP at the crossroad of signaling pathways reorganizing the actin cytoskeleton in DictyosteliumExperimental cell research. 127-40.
    2009 Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticksThe Journal of Infectious Diseases. 1331-40.
    2008 A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticksThe Journal of Infectious Diseases. 148-55.
    2007 Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticksPLoS pathogens. e33.
    2007 Role of outer surface protein D in the Borrelia burgdorferi life cycleInfection and immunity. 4237-44.
    2005 Genome variations in commensal and pathogenic E. coliUniversity of Cologne.
    2002 Oxidative cleavage of DNA by a dipyridoquinoxaline copper(II) complex in the presence of ascorbic acidJournal of inorganic biochemistry. 191-6.
    2002 Syntheses, Crystal Structyure, and Nuclease activity of Oxalato-Bridged Dicopper (II) complexes with Planar N-Donor Heterocyclic basesEur J Inorg Chem.

    Chapters

    Year Title
    2014 Bacterial, Protozoan and Viral Life-threatening DiseasesDiseases and Theranostics, Biotechnology (multi-volume set). Studium Press LLC.
    2014 Vector-borne diseasesDiseases and Theranostics, Biotechnology (multi-volume set). Studium Press LLC.

    Research Overview

  • Vector-borne diseases, Microbial pathogenesis, Infectious diseases, host-pathogen interaction, Vector biology
  • Expertise Keywords

  • Insects : cold tolerance and adaptation in arthropods, Gene regulation, Arthropod physiology, genomics,
  • Microbiology : Infectious diseases, Vector-borne diseases, microbial pathogenesis, host-pathogen interctions, symbiosis, microbial genetics and genomics,
  • Education And Training

  • Ph.D. in Microbial Genetics & Genomics, University of Cologne 2005
  • Full Name

  • Girish Neelakanta