Selected Publications

Articles In Academic Journals

Year Title
2017 A nutrient-regulated cyclic diguanylate phosphodiesterase controls Clostridium difficile biofilm and toxin production during stationary phase.  Infection and immunity. 1-17.
2016 Cyclic diguanylate signaling in Gram-positive bacteria.  FEMS microbiology reviews. 753-73.
2015 Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.  Journal of bacteriology. 819-32.
2015 Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile.  Journal of bacteriology. 565-77.
2013 Identification and characterization of cyclic nucleotide phosphodiesterases.  Methods in molecular biology (Clifton, N.J.). 235-43.
2013 The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD.  Journal of bacteriology. 5174-85.
2012 Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile.  Journal of bacteriology. 3307-16.
2010 An analysis of the solution structure and signaling mechanism of LovK, a sensor histidine kinase integrating light and redox signals.  Biochemistry. 6761-70.
2010 Electronic and protein structural dynamics of a photosensory histidine kinase.  Biochemistry. 4752-9.
2008 Photoregulation in prokaryotes.  Current opinion in microbiology. 168-78.
2008 Two-component signaling systems and cell cycle control in Caulobacter crescentus.  Advances in experimental medicine and biology. 122-30.
2007 A photosensory two-component system regulates bacterial cell attachment.  Proceedings of the National Academy of Sciences of the United States of America. 18241-6.
2007 Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism.  Biochemistry. 3614-23.
2004 Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli.  Photochemistry and photobiology. 542-7.

Research Overview

  • small molecule signaling contributing to virulence and persistence in Clostridium difficile

    • Grants

    Expertise Keywords

  • Microbiology : Signal transduction, bacterial antibiotic resistance

    • Education And Training

  • Ph.D. in Biochemistry and Molecular Biology, The University of Chicago 2011

    • Full Name

  • Erin Purcell