Selected Publications

Articles In Academic Journals

Year Title
2010 T-cells and B-cells in Systemic SclerosisCurrent Rheumatology Reviews. 276-282.
2009 Differential expression of CD3-Zeta message and protein in tumor infiltrating lymphocytes from solid tumor specimens and malignant ascites from patients with ovarian carcinomaAnticancer Research. 4673-4682.
2008 Aortic Aneurysms: an Immune Disease with a Strong Genetic ComponentCirculation. 242-2452.
2007 Aortic aneurysm: search for the triggerAnnals of Vascular Surgery. 292-295.
2007 Human Autoimmune Diseases are Specific Antigen-Driven T-Cell Diseases: Identification of the AntigensImmunologic Research. 359-372.
2007 The role of T cells in the pathogenesis of osteoarthritis. Arthritis and RheumatismArthritis and Rheumatism. 409-424.
2006 Systemic sclerosis: The role of immune cellsNature Clinical Practice Rheumatology. 679-685.
2006 The Abdominal Aortic Aneurysm (AAA) is a specific antigen-driven T-cell diseaseAnnals of the New York Academy of Science. 224-235.
2005 Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancerHuman Immunology. 554-562.
2005 Oligoclonal T cells are infiltrating the brain of children with AIDS: Sequence analysis revealed high proportions of identical beta-chain T-cell receptor (TCR) transcriptsClinical and Experimental Immunology. 338-356.
2005 Substantial proportions of identical b-chain T-cell receptor (TCR) transcripts are present in epithelial ovarian carcinoma tumors (EOC)Cellular Immunology. 81-101.
2004 Decreased expression of CD3zeta chain in T cells infiltrating the synovial membrane (SM) of patients with Osteoarthritis (OA)Clinical Diagnostic Laboratory Immunology. 195-202.
2004 Is Systemic Sclerosis an Antigen-driven T-cell Disease?Arthritis and Rheumatism. 1721-1733.
2004 Theiler's Virus Infection: A Model for Multiple SclerosisClinical Microbiology Reviews. 174-207.
2003 Apoptosis of infiltrating T cells in the CNS of mice infected with Theiler's Murine encephalomyelitis virus (TMEV)Virology. 110-123.
2003 Apoptosis of infiltrating T cells in the CNS of mice infected with Theiler's Murine encephalomyelitis virus (TMEV). Virology, 315, 110-123, 2003.Virology. 110-123.
2003 Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of cardiac allografts with chronic rejectionCellular Immunology. 75-90.
2003 Immune responses to human tumors: Development of tumor vaccinesAnticancer Research. 1969-1996.
2002 Oligoclonal T-cell expansion in the skin of patients with systemic sclerosisJournal of Immunology. 3649-3659.
2002 Phase I study of intraperitoneal rh-IL-12 in patients with Mullerian, Gastrointenstinal Primary Malignancies and MesotheliomaClinical Cancer Research. 3686-3695.
2001 Apoptosis in chronic rejection of human cardiac allograftsTransplantation. 1137-1146.
2001 Coronary arteries with chronic rejection contain oligoclonal T cells. Persistence of clonally expanded T-cell receptor (TCR) transcripts from the early post-transplantation period through chronic rejectionTransplantation Proceedings. 452-455.
2001 Gamma-chain T-cell receptor (TCR) transcripts are clonally expanded in the coronary arteries from cardiac allografts from patients with chronic rejectionTransplantation Proceedings. 456-458.
2001 Oligoclonal T cells are present in the CSF of a child with a recurrent disseminated MS-like demyelinating disease following Hepatitis A infectionClinical and Diagnostic Laboratory Immunology. 984-92.
2001 Oligoclonal T cells are present in the CSF of a child with a recurrent disseminated MS-like demyelinating disease follwing Hepatitis A infectonClinical and Diagnostic Laboratory Immunology. 984-992.
2001 Pathogenesis of Abdominal Aortic Aneurisms: A Multidisciplina Research Program Supported by the National Heart, Lung, and Blood InstituteJournal of Vascular Surgery. 730-8.
2000 Clinical and biological effects of intraperitoneal injections of recombinant IFN-alpha and recombinant IL-2 with or without tumor infiltrating lymphocytes in patients with ovarian or peritoneal carcinomaClinical Cancer Research. 2268-2278.
2000 Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal populations of T cells. Persistence of identical clonally expanded beta-chain T-cell receptor transcripts from the early posttransplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)Journal of Immunology. 369-384.
2000 Differential expression of TGF-beta, IL-2 and other cytokines in the CNS of TMEV-infected susceptible and resistant strains of miceVirology. 346-360.
2000 Expression of costimulatory molecules CD80 and CD86 and their receptors on tumor infiltrating lymphocytes from patients with ovarian carcinoma and other peritoneal carcinomatosisClinical and Experimental Immunology. 19-27.
1999 Angiocentric CD3+ T-cell infiltrates in HIV-1 associate CNS disease in childrenClinical and Diagnostic Laboratory Immunology. 105-114.
1999 Angiocentric CD3+ T-cell infiltrates in Human immunodeficiency virus type-1-associated central nervous system disease in childrenClinical and Diagnostic Laboratory Immunology. 105-114.
1999 Identification of an IL-10-producing, HLA-DR-negative, monocyte subset in the malignant ascites of patients with ovarian carcinoma, which inhibits cytokine protein expression and proliferation of autologous T cellsJournal of Immunology. 6251-6260.
1999 Increased levels of alternatively spliced IL-4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosisClinical and Diagnostic Laboratory Immunology. 660-664.
1999 Quantitative analysis of transforming growth factor-beta (TGF-?) and HLA class I and II in epithelial ovarian cancerClinical Cancer Research. 2498-2505.
1998 Amplification of T-cell receptor alpha- and beta-chain transcripts from mouse spleen lymphocytes by the nonpalindromic adaptor polymerase chain reaction. Hematopathology and Molecular Hematology 11 73-88 1998Hematopathology and Molecular Hematology. 73-88.
1998 Amplification of murine alpha and beta-chain T-cell receptor transcripts by the nonpalindromic adaptor polymerase chain reactionHematopathology and Molecular Hemtology. 73-88.
1998 Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumour specimens, peritoneal exudate cells containing tumour, tumour-infiltrating lymphocyte (TIL)-derived T-cell lines and established tumour cell linesClinical and Experimental Immunology. 172-180.
1998 Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritisCellular Immunology. 105-110.
1998 Intraperitoneal immunotherapy of peritoneal carcinomatosis. Cytokines.Cellular and Molecular Therapy. 121-140.
1998 Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvisClinical Cancer Research. 799-809.
1998 Reverse transcription-PCR quantitation of cytokine responses in vivo from specimens containing small numbers of cells during immunotherapyJournal of Immunological Methods. 169-179.
1998 T cells and T-cell derived cytokine transcripts in the synovial membrane of patients with osteoarthritis.Clinical and Diagnostic Laboratory Immunology. 430-437.
1998 T cells infiltrating coronary arteries of cardiac allografts with chronic rejection contain clonally expanded T lymphocytesTransplantation Proceedings. 1002-1004.
1997 All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1Experimental Cell Research. 277-286.
1997 An anti-LFA-1 monoclonal antibody (LDA-8) induces cellular aggregation of human lymphoblastoid cell lines and peripheral blood lymphocytesHematopathology and Molecular Hematology. 29-40.
1997 An anti-LFA-1 monoclonal antibody induces cellular aggregation of human lymphoblastoid cell lines and peripheral blood lymphocytesHematopathology and Molecular Hemtology. 29-40.
1996 Association of HLA-DQB1*0301 with Malignant MelanomaJournal of Immunotherapy. 381-383.
1996 HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2Cellular Immunology. 116-128.
1996 Immunopharmacology and cytokine production of a low dose schedule of intraperitoneally administered human recombinant interleukin-2 in patients with advanced epithelial ovarian carcinomaJournal of Immunotherapy. 443-451.
1996 Use of a retroviral vector to study the trafficking patterns of purified ovarian tumor-infiltrating lymphocytes (TIL) used in intraperitoneal adoptive immunotherapy of ovarian cancer patients - A pilot studyHuman Gene Therapy. 1351-1365.
1995 Immunology of Theiler's Murine Encephalomyelitis Virus infectionImmunologic Research. 13-33.
1992 Human T-cell hybridoma-derived suppressor factor 160 and transforming growth factor-beta are different moleculesLympokine and Cytokine Research. 307-315.
1991 Hybridoma-derived human suppressor factors: Inhibition of growth of tumor cell lines and effect on cytotoxic cellsHuman Antibodies and Hybridomas. 160-169.
1989 Regulation of natural killer cytotoxicity by recombinant aplpha interferons. Augmentation by interferon alpha-7, an interferon similar to interferon alpha JAnticancer Research. 849-858.
1988 Differential effects of human alpha and gamma interferon on mixed lymphocyte culture and on T-cell-mediated cytotoxicity. Inhibition of proliferation but not of IL-2 production by alpha interferonsInternational Archives of Allergy and Applied Immunology. 361-369.
1986 Immunomodulation of human leukocytes by staphylococcal enterotoxin A, a gamma interferon inducer. Augmentation of natural killer cells and induction of suppressor cellsCellular Immunology. 371-385.

Books

Year Title
1990 Analysis of T-cell receptor and immunoglobulin cDNAs by the nonpalindromic adaptor polymerase chain reaction. In: Gene and Chromosome Analysis, Part C.  Ed. 5.  Orlando, FL.

Conference Papers

Year Title
2001 Perspectives on the Application of Genomics, Transcriptomics (DNA Arrays), and Proteinomics to the Diagnosis and Treatment of Cancer.  307-311.
1997 Biological therapies of cancer based on T lymphocytes.  130-134.

Education And Training

  • D.Sc. in Molecular Biology and Genetics, Democritus University of Thrace 2008
  • Ph.D. in Nutritional Biochemistry and Metabolism, Massachusetts Institute of Technology 1978
  • B.S. in Chemistry, University of Patras 1973
  • Full Name

  • Chris Platsoucas