Selected Publications

Articles In Academic Journals

Year Title
2010 T-cells and B-cells in Systemic SclerosisCurrent Rheumatology Reviews. 276-282.
2009 Differential expression of CD3-Zeta message and protein in tumor infiltrating lymphocytes from solid tumor specimens and malignant ascites from patients with ovarian carcinomaAnticancer Research. 4673-4682.
2008 Aortic Aneurysms: an Immune Disease with a Strong Genetic ComponentCirculation. 242-2452.
2007 Aortic aneurysm: search for the triggerAnnals of Vascular Surgery. 292-295.
2007 Human Autoimmune Diseases are Specific Antigen-Driven T-Cell Diseases: Identification of the AntigensImmunologic Research. 359-372.
2007 The role of T cells in the pathogenesis of osteoarthritis. Arthritis and RheumatismArthritis and Rheumatism. 409-424.
2006 Systemic sclerosis: The role of immune cellsNature Clinical Practice Rheumatology. 679-685.
2006 The Abdominal Aortic Aneurysm (AAA) is a specific antigen-driven T-cell diseaseAnnals of the New York Academy of Science. 224-235.
2005 Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancerHuman Immunology. 554-562.
2005 Oligoclonal T cells are infiltrating the brain of children with AIDS: Sequence analysis revealed high proportions of identical beta-chain T-cell receptor (TCR) transcriptsClinical and Experimental Immunology. 338-356.
2005 Substantial proportions of identical b-chain T-cell receptor (TCR) transcripts are present in epithelial ovarian carcinoma tumors (EOC)Cellular Immunology. 81-101.
2004 Decreased expression of CD3zeta chain in T cells infiltrating the synovial membrane (SM) of patients with Osteoarthritis (OA)Clinical Diagnostic Laboratory Immunology. 195-202.
2004 Is Systemic Sclerosis an Antigen-driven T-cell Disease?Arthritis and Rheumatism. 1721-1733.
2004 Theiler's Virus Infection: A Model for Multiple SclerosisClinical Microbiology Reviews. 174-207.
2003 Apoptosis of infiltrating T cells in the CNS of mice infected with Theiler's Murine encephalomyelitis virus (TMEV)Virology. 110-123.
2003 Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of cardiac allografts with chronic rejectionCellular Immunology. 75-90.
2003 Immune responses to human tumors: Development of tumor vaccinesAnticancer Research. 1969-1996.
2002 Oligoclonal T-cell expansion in the skin of patients with systemic sclerosisJournal of Immunology. 3649-3659.
2002 Phase I study of intraperitoneal rh-IL-12 in patients with Mullerian, Gastrointenstinal Primary Malignancies and MesotheliomaClinical Cancer Research. 3686-3695.
2001 Apoptosis in chronic rejection of human cardiac allograftsTransplantation. 1137-1146.
2001 Coronary arteries with chronic rejection contain oligoclonal T cells. Persistence of clonally expanded T-cell receptor (TCR) transcripts from the early post-transplantation period through chronic rejectionTransplantation Proceedings. 452-455.
2001 Gamma-chain T-cell receptor (TCR) transcripts are clonally expanded in the coronary arteries from cardiac allografts from patients with chronic rejectionTransplantation Proceedings. 456-458.
2001 Oligoclonal T cells are present in the CSF of a child with a recurrent disseminated MS-like demyelinating disease following Hepatitis A infectionClinical and Diagnostic Laboratory Immunology. 984-92.
2001 Oligoclonal T cells are present in the CSF of a child with a recurrent disseminated MS-like demyelinating disease follwing Hepatitis A infectonClinical and Diagnostic Laboratory Immunology. 984-992.
2001 Pathogenesis of Abdominal Aortic Aneurisms: A Multidisciplina Research Program Supported by the National Heart, Lung, and Blood InstituteJournal of Vascular Surgery. 730-8.
2000 Clinical and biological effects of intraperitoneal injections of recombinant IFN-alpha and recombinant IL-2 with or without tumor infiltrating lymphocytes in patients with ovarian or peritoneal carcinomaClinical Cancer Research. 2268-2278.
2000 Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal populations of T cells. Persistence of identical clonally expanded beta-chain T-cell receptor transcripts from the early posttransplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)Journal of Immunology. 369-384.
2000 Differential expression of TGF-beta, IL-2 and other cytokines in the CNS of TMEV-infected susceptible and resistant strains of miceVirology. 346-360.
2000 Expression of costimulatory molecules CD80 and CD86 and their receptors on tumor infiltrating lymphocytes from patients with ovarian carcinoma and other peritoneal carcinomatosisClinical and Experimental Immunology. 19-27.
1999 Angiocentric CD3+ T-cell infiltrates in HIV-1 associate CNS disease in childrenClinical and Diagnostic Laboratory Immunology. 105-114.
1999 Angiocentric CD3+ T-cell infiltrates in Human immunodeficiency virus type-1-associated central nervous system disease in childrenClinical and Diagnostic Laboratory Immunology. 105-114.
1999 Identification of an IL-10-producing, HLA-DR-negative, monocyte subset in the malignant ascites of patients with ovarian carcinoma, which inhibits cytokine protein expression and proliferation of autologous T cellsJournal of Immunology. 6251-6260.
1999 Increased levels of alternatively spliced IL-4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosisClinical and Diagnostic Laboratory Immunology. 660-664.
1999 Quantitative analysis of transforming growth factor-beta (TGF-?) and HLA class I and II in epithelial ovarian cancerClinical Cancer Research. 2498-2505.
1998 Amplification of T-cell receptor alpha- and beta-chain transcripts from mouse spleen lymphocytes by the nonpalindromic adaptor polymerase chain reactionHematopathology and Molecular Hematology. 73-88.
1998 Amplification of T-cell receptor alpha- and beta-chain transcripts from mouse spleen lymphocytes by the nonpalindromic adaptor polymerase chain reaction. Hematopathology and Molecular Hematology 11 73-88 1998Hematopathology and Molecular Hematology. 73-88.
1998 Amplification of murine alpha and beta-chain T-cell receptor transcripts by the nonpalindromic adaptor polymerase chain reactionHematopathology and Molecular Hemtology. 73-88.
1998 Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumour specimens, peritoneal exudate cells containing tumour, tumour-infiltrating lymphocyte (TIL)-derived T-cell lines and established tumour cell linesClinical and Experimental Immunology. 172-180.
1998 Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritisCellular Immunology. 105-110.
1998 Intraperitoneal immunotherapy of peritoneal carcinomatosis. Cytokines.Cellular and Molecular Therapy. 121-140.
1998 Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvisClinical Cancer Research. 799-809.
1998 Reverse transcription-PCR quantitation of cytokine responses in vivo from specimens containing small numbers of cells during immunotherapyJournal of Immunological Methods. 169-179.
1998 T cells and T-cell derived cytokine transcripts in the synovial membrane of patients with osteoarthritis.Clinical and Diagnostic Laboratory Immunology. 430-437.
1998 T cells infiltrating coronary arteries of cardiac allografts with chronic rejection contain clonally expanded T lymphocytesTransplantation Proceedings. 1002-1004.
1997 All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1Experimental cell research. 277-286.
1997 An anti-LFA-1 monoclonal antibody (LDA-8) induces cellular aggregation of human lymphoblastoid cell lines and peripheral blood lymphocytesHematopathology and Molecular Hematology. 29-40.
1997 An anti-LFA-1 monoclonal antibody induces cellular aggregation of human lymphoblastoid cell lines and peripheral blood lymphocytesHematopathology and Molecular Hemtology. 29-40.
1996 Association of HLA-DQB1*0301 with Malignant MelanomaJournal of Immunotherapy. 381-383.
1996 HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2Cellular Immunology. 116-128.
1996 Immunopharmacology and cytokine production of a low dose schedule of intraperitoneally administered human recombinant interleukin-2 in patients with advanced epithelial ovarian carcinomaJournal of Immunotherapy. 443-451.
1996 Use of a retroviral vector to study the trafficking patterns of purified ovarian tumor-infiltrating lymphocytes (TIL) used in intraperitoneal adoptive immunotherapy of ovarian cancer patients - A pilot studyHuman Gene Therapy. 1351-1365.
1995 Immunology of Theiler's Murine Encephalomyelitis Virus infectionImmunologic Research. 13-33.
1992 Human T-cell hybridoma-derived suppressor factor 160 and transforming growth factor-beta are different moleculesLympokine and Cytokine Research. 307-315.
1991 Hybridoma-derived human suppressor factors: Inhibition of growth of tumor cell lines and effect on cytotoxic cellsHuman Antibodies and Hybridomas. 160-169.
1989 Regulation of natural killer cytotoxicity by recombinant aplpha interferons. Augmentation by interferon alpha-7, an interferon similar to interferon alpha JAnticancer Research. 849-858.
1988 Differential effects of human alpha and gamma interferon on mixed lymphocyte culture and on T-cell-mediated cytotoxicity. Inhibition of proliferation but not of IL-2 production by alpha interferonsInternational Archives of Allergy and Applied Immunology. 361-369.
1986 Immunomodulation of human leukocytes by staphylococcal enterotoxin A, a gamma interferon inducer. Augmentation of natural killer cells and induction of suppressor cellsCellular Immunology. 371-385.

Books

Year Title
1990 Analysis of T-cell receptor and immunoglobulin cDNAs by the nonpalindromic adaptor polymerase chain reaction.  Ed. 5.  Orlando, FL: Methods in Molecular Genetics, Academic Press, Inc..

Chapters

Year Title
1998 "Structure and function of the trimolecular complex: T-cell receptor/peptide/MHC"Current Topics in Biochemistry. Thessaloniki: Aristotelian University of Thessaloniki, Laboratory of Biochemistry Press.
1998 Progress toward tumor-specific immunity in carcinomas of the ovary and breastCancer in Women. Oxford, London, Berlin, Tokyo: Blackwell Science Publication.

Conference Papers

Year Title
2001 Perspectives on the Application of Genomics, Transcriptomics (DNA Arrays), and Proteinomics to the Diagnosis and Treatment of Cancer.  307-311.
1997 Biological therapies of cancer based on T lymphocytes.  130-134.

Education And Training

  • D.Sc. in Molecular Biology and Genetics, Democritus University of Thrace 2008
  • Ph.D. in Nutritional Biochemistry and Metabolism, Massachusetts Institute of Technology 1978
  • B.S. in Chemistry, University of Patras 1973
  • Full Name

  • Chris Platsoucas