Overview

  • Alvin Holder is an Associate Professor of Chemistry at Old Dominion University (ODU). His research focus involves bioinorganic chemistry, which is currently funded by an NSF CAREER award. Since the start of his career, he has supported and supervised more than 100 undergraduate, graduate, and post-doctoral trainees both in Barbados and the U.S.A., many of whom are from underrepresented groups.
  • Selected Publications

    Articles In Academic Journals

    Year Title
    2018 Catalytic Oxidation of Lignin Model Compounds using a Cobalt (III) Cubane Complex
    2018 Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.Biochimica et biophysica acta. 40-50.
    2017 1-D calcium, 2-D zinc and 3-D manganese coordination polymers derived from pyrazine-2, 3, 5, 6-tetracarboxylic acidInorganica Chimica Acta. 163-168.
    2017 A Small Molecule Derivative as a Targeting Agent for Sp1 and Survivin Effectively Suppresses Pancreatic Cancer Cell Growth
    2017 An enhanced rheometer inertia correction procedure (ERIC) for the study of gelling systems using combined motor-transducer rheometersPhysics of Fluids. 121602.
    2017 Application of micellar enhanced ultrafiltration for the removal of sunset yellow dye from aqueous mediaJournal of Dispersion Science and Technology. 139-144.
    2017 Basic Coordination Chemistry of RutheniumRuthenium Complexes: Photochemical and Biomedical Applications. 25.
    2017 COPPER-TOLFENAMIC ACID INHIBITS BREAST CANCER CELL GROWTH VIA CELL CYCLE ARREST AND APOPTOSIS
    2017 Coordination of different complexes to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytesBiochimica et biophysica acta.
    2017 How Virginia Tech placed me on the map from May 2002 to June 2003! A bridge to my futureInorganica Chimica Acta. 1-3.
    2017 Kinetics and mechanism of the oxidation of a cobaloxime by sodium hypochlorite in aqueous solution: Is it an outer-sphere mechanism?Inorganica Chimica Acta. 254-265.
    2017 Photodynamic Therapy in Medicine with Mixed-Metal/Supramolecular ComplexesRuthenium Complexes: Photochemical and Biomedical Applications. 139.
    2017 Ruthenium-and Cobalt-Containing Complexes and Hydrogenases for Hydrogen ProductionRuthenium Complexes: Photochemical and Biomedical Applications. 67.
    2017 The Use of Inorganic Compounds in Photodynamic Therapy: Improvements in Methods and Photosensitizer DesignRecent Patents on Nanotechnology. 3-14.
    2016 A novel copper (II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase II$?$Inorganic chemistry communications. 45-49.
    2016 An in vitro study on the effect of synthesized tin (IV) complexes on glioblastoma, colorectal, and skin cancer cell linesBiomed. Res. Clin. Pract. 7-15.
    2016 Anticancer, biophysical and computational investigations of half-sandwich ruthenium (II) thiosemicarbazone complexes: The effect of arene versus thiacrown face-capInterdisciplinary Journal of Chemistry. 1-15.
    2016 Assessing the stability of the Co (I) species of two mononuclear dichlorocobalt compounds bearing 2, 2?-bipyridine and trans-2-(2?-quiolyl) methylene-3-quinuclidione via 59 Co NMR spectroscopy, electrochemical, and catalyzed proton electroreduction studiesInorganica Chimica Acta. 157-168.
    2016 Computational, electrochemical, and spectroscopic studies of two mononuclear cobaloximes: the influence of an axial pyridine and solvent on the redox behavior and evidence for pyridine coordination to cobalt(I) and cobalt(II) metal centresDalton Transactions. 10326-10342.
    2016 High performance tunable piezoresistive pressure sensor based on direct contact between printed graphene nanoplatelet composite layersRsc Advances. 105206-105210.
    2016 Synthesis and characterization of azo-guanidine based alcoholic media naked eye DNA sensorRoyal Society Open Science. 160351.
    2016 Vanadium Toxicological Potential versus Its Pharmacological Activity: New Developments and ResearchOxidative Medicine and Cellular Longevity.
    2015 Assessment of the stress relaxation characteristics of critical gels formed under unidirectional shear flow by controlled stress parallel superposition rheometryJournal of Non-Newtonian Fluid Mechanics. 227-233.
    2015 Complex three-dimensional lanthanide metal–organic frameworks with variable coordination spheres based on pyrazine-2, 3, 5, 6-tetracarboxylateCrystEngComm. 5377-5388.
    2015 Interesting properties of p-, d-, and f-block elements when coordinated with dipicolinic acid and its derivatives as ligands: their use as inorganic pharmaceuticalsReviews in Inorganic Chemistry. 57-67.
    2015 Meet Our Editorial Board MemberRecent Patents on Nanotechnology. 149-149.
    2015 Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potentialBioorganic & Medicinal Chemistry Letters. 5566-5569.
    2015 Synthesis, X-ray Crystallographic, Electrochemical, and Spectroscopic Studies of Bis-(1, 10-phenanthroline)(2, 2?-bipyridine) cobalt (III) HexafluorophosphateJournal of Chemical Crystallography. 427-433.
    2015 Validation of optimal Fourier rheometry for rapidly gelling materials and its application in the study of collagen gelationJournal of Non-Newtonian Fluid Mechanics. 253-259.
    2014 Characterization and functional assessment of a cobalt(III)-oxo cubane cluster water oxidation catalyst immobilized on ITOCatal. Commun.. 76-80.
    2014 Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluationEur. J. Med. Chem.. 81-86.
    2014 Spectroscopic Characterization of L-ascorbic Acid-induced Reduction of Vanadium(V) Dipicolinates: Formation of Vanadium(III) and Vanadium(IV) Complexes from Vanadium(V) Dipicolinate DerivativesInorg. Chim. Acta. 112-119.
    2013 A Comparison of the Self Assembled Frameworks of Three Cobalt(II) Coordination Compounds Bearing Dipicolinic Acid and Chelidamic Acid LigandsJ. Chem. Crystallogr.. 509-516.
    2013 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 119.
    2013 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 317-339.
    2013 Iodido $\{$4-phenyl-1-[1-(1, 3-thiazol-2-yl-N) ethylidene] thiosemicarbazidato-2N', S$\}$$\{$4-phenyl-1-[1-(1, 3-thiazol-2-yl) ethylidene] thiosemicarbazide-S$\}$ cadmium (II)
    2013 Photocatalytic hydrogen production with mixed-metal binuclear ruthenium (II)-cobalt (II) complexes: What a difference bridging and terminal ligands can make.
    2013 Preliminary anti-cancer photodynamic therapeutic in vitro studies with mixed-metal binuclear ruthenium(II)-vanadium(IV) complexesDalton Trans.. 11881-11899.
    2013 Synthesis, characterisation, and preliminary anti-cancer photodynamic therapeutic in vitro studies of mixed-metal binuclear ruthenium (II)-vanadium (IV) complexesDalton transactions (Cambridge, England: 2003). 11881.
    2013 Synthesis, crystal structure of Zn (II) complex of 2-acetylthiazole N-phenyl-3-thiosemicarbazone
    2012 A novel ruthenium(II)-cobaloxime supramolecular complex for photocatalytic H2 evolution: synthesis, characterisation and mechanistic studiesDalton Trans.. 13060-13073.
    2012 Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo [d][1, 3] dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamidesInorganic chemistry communications. 225-229.
    2012 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 350-368.
    2012 Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed LigandsEur. J. Inorg. Chem.. 664-677.
    2011 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 163.
    2011 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 359-378.
    2010 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 176-185.
    2010 Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadiumInhalation Toxicol.. 169-178.
    2010 Inhibition of Ab42 Peptide Aggregation by a Binuclear Ruthenium(II)-Platinum(II) Complex: Potential for Multimetal Organometallics as Anti-amyloid AgentsACS Chem. Neurosci.. 691-701.
    2010 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 504-525.
    2009 A new and efficient synthetic route for the synthesis of 3, 6-dimethylpyrazine-2, 5-dicarboxylic acid hydrate: molecular structure and unique supramolecular interactionsCrystEngComm. 580-582.
    2009 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 201-210.
    2009 Complexation of bisphosphonates with ytterbium(III): Application of phosphate and ATP detection assay based on Yb3+-pyrocatechol violetJ. Inorg. Biochem.. 1652-1657.
    2009 Dynamic studies of transnitrosation of thiols of biological importance by the nitrosated 4,4’,4”,4”’-tetrasulfophthalocyaninecobaltate(III) anion in aqueous solutionBiophysical Chemistry. 198-202.
    2009 Electrochemical and Electrogenerated Chemiluminescent Studies of a Trinuclear Complex, [((phen)2Ru(dpp))2RhCl2]5+, and Its Interactions with Calf Thymus DNAAnal. Chem.. 4068-4075.
    2009 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 505-524.
    2009 Microwave synthesis of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicityDalton Trans.. 10757-10764.
    2008 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 167-177.
    2008 Inorganic pharmaceuticalsAnnual Reports Section" A"(Inorganic Chemistry). 477-497.
    2008 Metal complexation chemistry used for phosphate and nucleotide determination: an investigation of the Yb3+–pyrocatechol violet sensorJBIC Journal of Biological Inorganic Chemistry. 1291-1299.
    2008 Tetra-$\mu$-aqua-octaaquabis ($\mu$-4-chloropyridine-2, 6-dicarboxylato) bis (4-chloropyridine-2, 6-dicarboxylato) tricobalt (II) disodium (I) bis [triaquabis (4-chloropyridine-2, 6-dicarboxylato) cobalt (II)] hexahydrateActa Crystallographica Section E: Structure Reports Online. m262.
    2008 Tetra-?-aqua-octaaquabis (?-4-chloropyridine-2, 6-dicarboxylato) bis (4-chloropyridine-2, 6-dicarboxylato) tricobalt (II) disodium (I) bis [triaquabis (4-chloropyridine-2, 6-dicarboxylato) cobalt (II)] hexahydrateActa Crystallographica Section E: Structure Reports Online. m262-m263.
    2007 Chelation of vanadium (V) by difluoromethylene bisphosphonate, a structural analogue of pyrophosphateInorganic chemistry. 6723-6732.
    2007 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 159-169.
    2007 Photobiological Impact of [{(bpy) 2Ru (dpp)} 2RhCl2] Cl5 and [{(bpy) 2Os (dpp)} 2RhCl2] Cl5 [bpy= 2, 2 ‘-Bipyridine; dpp= 2, 3-Bis (2-pyridyl) pyrazine] on Vero CellsInorganic chemistry. 4760-4762.
    2007 Potassium (4-carboxypyridine-2, 6-dicarboxylato) dioxidovanadate (V) monohydrateActa Crystallographica Section E: Structure Reports Online. m2051-m2052.
    2007 Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: vanadium agentsJournal of immunotoxicology. 49-60.
    2007 Synthesis and Crystal Structure of Tris (1, 10-phenanthroline) iron (II) perchlorate ethanol monosolvate hemihydrateAnalytical Sciences: X-ray Structure Analysis Online. X169-X170.
    2007 The crystal structure of a bis (2, 6-pyridinedicarboxylato) chromate (III) anion with an elaborate network of hydrogen bonding and $?$ stackingJournal of Chemical Crystallography. 309-314.
    2007 The crystal structure of a bis (2, 6-pyridinedicarboxylato) chromate (III) anion with an elaborate network of hydrogen bonding and $\pi$ stackingJournal of Chemical Crystallography. 309.
    2006 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 194-220.
    2006 Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: chromium agentsJournal of immunotoxicology. 69-81.
    2006 Reduction of vanadium (V) by L-ascorbic acid at low and neutral pH: kinetic, mechanistic, and spectroscopic characterizationInorganic chemistry. 1471-1479.
    2005 5-[(4-Methylphenyl) diazenyl] salicylaldehydeActa Crystallographica Section E: Structure Reports Online. o1611.
    2005 Chromium, molybdenum and tungstenAnnual Reports Section" A"(Inorganic Chemistry). 161-193.
    2005 Synthesis, spectroscopic and structural analysis of 5-(4-methylphenyldiazenyl)salicylaldehyde.Acta Crystallographica Section E: Structure Reports Online. o1611-o1613.
    2004 Design aspects for the development of mixed-metal supramolecular complexes capable of visible light induced photocleavage of DNAInorganic chemistry. 303-308.
    2004 Synthesis and structure of [(nitrito-O, O?) bis (di-2-pyridylamine) copper (II)] nitriteJournal of Chemical Crystallography. 383-386.
    2003 The mechanism of the decomposition of a bronchodilator, S-nitroso-N-acetyl-D, L-penicillamine (SNAP), by a bronchoconstrictor, Aqueous sulfite: Detection of the N-nitrosohydroxylamine-N-sulfonate ionBulletin of the Korean Chemical Society. 350-356.
    2002 DNA binding of mixed-metal supramolecular Ru, Pt complexesInorganic chemistry communications. 1078-1081.
    2002 Kinetics and mechanism of the reduction of the molybdatopentaamminecobalt (III) ion by aqueous sulfite and aqueous potassium hexacyanoferrate (II)Inorganica Chimica Acta. 279-289.
    2000 Mechanism of the oxidation of L-ascorbic acid by the bis (pyridine-2, 6-dicarboxylate) cobaltate (III) ion in aqueous solutionTransition metal chemistry. 605-611.
    1999 Synthesis, Acid Hydrolysis and Formation of the Molybdatopentaamminechromium (III) Ion in Aqueous SolutionBioInorganic Reaction Mechanisms. 177-188.
    1997 Mechanism of the oxidation of l-ascorbic acid by the molyb-datopentaamminecobalt (III) ion in aqueous solutionTransition metal chemistry. 135-140.
    1997 Syntheses, characterisation, infrared and 95Mo NMR spectroscopy of some coordinated oxo—molybdenum (VI) complexesInorganica Chimica Acta. 225-228.
    1996 Interconversion and Reactivity of Two Heterometallic Tin-Containing Cuboidal Clusters from [Mo3S4 (H2O) 9] 4+: X-ray Structure of the Single Cube with an Mo3SnS4 CoreInorganic chemistry. 5525-5530.
    1996 Synthesis, acid hydrolysis and formation of the [(H 3 N) 5 CoOMoO 3]+ ion in aqueous solutionJournal of the Chemical Society, Dalton Transactions. 2637-2643.

    Books

    Year Title
    2013 Dedications and memories of two icons of Moly.  New York: Nova Science Publishers, Inc..
    2013 Molybdenum: Its history, occurance, breif inorganic and bioinorganic chemistry.  New York: Nova Science Publishers, Inc..
    2011 Dipicolinic acid, its analogues, and derivatives: aspects of their coordination chemistry.  New York: Nova Science Publishers.

    Chapters

    Year Title
    2014 Solving some of the world's problems with ruthenium complexes: Their use in solar energy capture and production of hydrogenRuthenium: Synthesis, Physicochemical Properties and Applications. Nova Science Publishers, Inc.
    2014 Solving some of the world's problems with ruthenium complexes; Their role in imaging and biomedical applicationsRuthenium: Synthesis, Physicochemical Properties and Applications. New York: Nova Science Publishers, Inc..
    2007 Do vanadium compounds drive reorganization of the plasma membrane and activation of insulin receptors with lipid rafts?ACS Symposium Series. ACS Publications.
    2005 "NO and NO Donors"Nitric Oxide Donors for Pharmaceutical and Biological Applications. USA: Wiley.

    Conference Papers

    Year Title
    2011 Novel chemotherapeutic agents of vanadium (IV) with thiosemithiocarbazones and Schiff bases as ligands: Structural and in vitro studies
    2008 FLUO 18-Synthesis and characterization of some fluorine-containing complexes of platinum (II): Use of 19F NMR in studying DNA interactions
    2008 INOR 614-Use of 19F NMR in studying DNA interactions with platinum (II) complexes
    2008 INOR 638-Syntheses and characterizations of some transition metal complexes containing analogs of 2, 6-pyridinedicarboxylic acid
    2006 Characterization of a soluble lead (II)-dipicolinate complex and its effect as a pulmonary immunomodulatory agent
    2006 INOR 75-Synthesis and characterization of some Schiff Base complexes of vanadium (V)-A search for an effective insulin-enhancing compound
    2006 INOR 78-Lipophilic vanadium compounds drive translocation of insulin receptors into rafts
    2006 INOR 832-Kinetics of NADH binding to aqueous vanadium (IV)
    2006 Interactions of NADH with aqueous vanadium (IV)
    2006 Ru, Os, Rh mixed-metal complexes are a potential novel class of oxygen independent photosensitizers for photodynamic therapy (PDT).  61391G-61391G.
    2005 AEI: Reactions of aqueous vanadium with NADH.  U2178-U2178.
    2005 Investigative study involving the interaction between the vanadyl cation and NADH in aqueous solution..  U1044-U1044.
    2005 Reinvestigation of the reduction of aqueous vanadium (V) by ascorbic acid: Evidence for both inner and outer sphere pathways..  U1049-U1049.
    2005 Syntheses and characterizations of some transition metal complexes containing 2, 6-pyridinedicarboxylic acid and various amines.  U2073-U2073.
    2005 The dynamic interaction of tetrasodium salt of cobalt (II)-4, 4’, 4”, 4”’-tetrasulfophthalocyanine (CoTSPc) and its nitrosated analogue, with various S-nitrosothiols and thiols respectively.  U2034-U2034.
    2004 Comparison of a series of phenanthrolinequinone thiosemicarbazone compounds..  U619-U619.
    2004 Light induced DNA cleavage and photodynamic therapy properties of MMCT states of rhodium centered supramolecular complexes..  U843-U844.
    2004 Photochemical reactivity of the MMCT states of rhodium (III) centered triads of ruthenium (II) and osmium (II): From photoinitiated electron collection to photodynamic therapy agents..  U1460-U1461.
    2003 Mixed-metal supramolecular complexes as photochemical molecular devices and DNA binding and photocleavage agents.  U64-U64.
    2003 Photochemical propertis of rhodium (III) centered triads of ruthenium (II) and osmium (II): Uses as photochemical molecular devices and DNA photocleavage agents..  U713-U714.
    2001 Kinetics and mechanism of the reaction of S-nitroso-N-acetyl-D, L penicillamine and aqueous sulfite..  U565-U565.
    1993 OXIDATION OF L-ASCORBIC-ACID BY THE MOLYBDATOPENTAAMMINECOBALT (III) ION IN AQUEOUS-SOLUTION.  614-INOR.

    Research Overview

  • My area of research revolves around biological and inorganic chemistry, bioinorganic and inorganic reaction mechanisms.
  • Grants

  • REU Site: Undergraduate Research Opportunities in Chemistry for Community College Students at Old Dominion University  awarded by National Science Foundation 2017 - 2020
  • Texas Center for Health Disparities Research Pilot Award  awarded by University of North Texas Health Science Center 2017 - 2018
  • CAREER: Ruthenium(II)-cobalt(II)/cobalt(III) mixed-metal complexes for photocatalytic hydrogen production from water  awarded by National Science Foundation CAREER Award 2012 - 2018
  • Novel Cobalt to Induce Therap in BCA 1  awarded by University of North Texas Health Center 2017
  • CAREER: Ruthenium(II)-cobalt(II)/cobalt(III) mixed-metal complexes for photocatalytic hydrogen production from water  awarded by National Science Foundation CAREER Award Summer REU supplement 2016 - 2017
  • REU NSF METAL COMP PHOTO WATER  awarded by NSF 2014 - 2017
  • NSF METAL COMP AND PHOTO WATER  awarded by NSF 2013 - 2017
  • Repairing a Leaky Science Pipeline: Generating a Catalyst for Science  awarded by The American Society for Microbiology (ASM)-NSF Leaders Inspiring Networks and Knowledge (LINK) Program 2015 - 2016
  • NSF REU Supplement from NSF Career Award  awarded by NSF 2014
  • Ruthenium(II)-cobalt(II)/cobalt(III) mixed-metal complexes for photocatalytic hydrogen production from water  awarded by National Science Foundation CAREER Award Summer REU supplement 2014
  • Biomedical Seed Grant Award.  awarded by MS-INBRE 2012 - 2013
  • Photosynthesis at the Microscale.  awarded by Department of the Army, Engineer Research and Development Center, Corps of Engineers, Construction Engineering Research Laboratory 2012
  • Biomedical Seed Grant Award  awarded by MS-INBRE 2011 - 2012
  • Photosynthesis at the Microscale  awarded by Department of the Army, Engineer Research and Development Center, Corps of Engineers, Construction Engineering Research Laboratory 2011
  • Synthesis, Characterization, and CO2 Sequestering Studies of Cobalt(III)-Containing Metallomesogens.  awarded by American Chemical Society 2011
  • The Boeing project 2010 - 2011
  • Acquisition of an EPR spectrometer at Southern Miss.  awarded by National Science Foundation 2008 - 2011
  • Biomedical Seed Grant Award  awarded by MS-INBRE 2010
  • Development of multimodal nanoparticle probes for in vivo bioimaging applications  awarded by USM 2008 - 2009
  • Synthesis, characterisation, and liquid phase studies of Schiff base complexes of novel titanium(IV) metallomesogens  awarded by The Royal Society of Chemistry Journals Grants for International Authors 2008
  • acquisition of a PAR electrochemical system for teaching and research  awarded by ExxonMobil Research and Engineering Company 2008
  • Knowledge Build Grant for use of selected transition metals in catalysis and the fight against cancer and diabetes  awarded by ExxonMobil Research and Engineering Company 2007 - 2008
  • fight against cancer with ruthenium compounds.  awarded by USM Lucas Endowment Grant 2007 - 2008
  • Division of Fluorine for the synthesis and characterization of novel fluorine-containing trinuclear ruthenium(II)/rhodium(III) complex  awarded by The American Chemical Society 2007
  • studies on the chemistry of rhenium complexes  awarded by A Royal Society of Chemistry John William Thomas Jones Research Fund 1999 - 2000
  • A Wellcome Trust International Research Development Award 1998 - 2000
  • studies on the chemistry of rhenium complexes  awarded by A Royal Society of Chemistry John William Thomas Jones Research Fund 1998 - 1999
  • A Wellcome Research Travel Grant 1998
  • Education And Training

  • Ph.D. in Inorganic Chemistry, University of the West Indies 1994
  • B.S. in Special Chemistry, University of West Indies 1989
  • Full Name

  • Alvin Holder